Dorothy M K Keefe Selected Research

Mucositis

9/2011	Animal models of mucositis: implications for therapy.
1/2010	Role of the cyclooxygenase pathway in chemotherapy-induced oral mucositis: a pilot study.
10/2009	Irinotecan-induced mucositis manifesting as diarrhoea corresponds with an amended intestinal flora and mucin profile.
6/2009	Irinotecan-induced mucositis is associated with changes in intestinal mucins.
4/2009	Gastrointestinal microflora and mucins may play a critical role in the development of 5-Fluorouracil-induced gastrointestinal mucositis.
1/2009	Is the pathobiology of chemotherapy-induced alimentary tract mucositis influenced by the type of mucotoxic drug administered?
1/2009	Chemotherapy-induced modifications to gastrointestinal microflora: evidence and implications of change.
6/2008	Characterisation of mucosal changes in the alimentary tract following administration of irinotecan: implications for the pathobiology of mucositis.
1/2008	New pathways for alimentary mucositis.
10/2007	Gene expression analysis of multiple gastrointestinal regions reveals activation of common cell regulatory pathways following cytotoxic chemotherapy.

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Dorothy M K Keefe Research Topics

Disease

29	Mucositis 09/2011 - 07/2002
28	Neoplasms (Cancer) 01/2019 - 07/2002
10	Diarrhea 01/2018 - 09/2003
7	Breast Neoplasms (Breast Cancer) 01/2019 - 07/2002
5	Nausea 01/2015 - 01/2015
5	Vomiting 01/2015 - 01/2015
3	Pain (Aches) 11/2018 - 01/2010
3	Weight Loss (Weight Reduction) 01/2018 - 02/2007
3	Colorectal Neoplasms (Colorectal Cancer) 02/2007 - 12/2005
2	Hemorrhage 11/2018 - 01/2017
2	Inflammation (Inflammations) 07/2013 - 02/2010
2	Stomatitis 01/2010 - 12/2005
2	Atrophy 06/2008 - 09/2003
1	Weight Gain 01/2017
1	Non-Hodgkin Lymphoma (Lymphosarcoma) 08/2013
1	Proctitis 01/2013
1	Oral Ulcer (Mouth Ulcer) 05/2007
1	Constipation 09/2006
1	Hematologic Neoplasms (Hematological Malignancy) 04/2006
1	Hyperplasia 09/2003

Drug/Important Bio-Agent (IBA)

13	Irinotecan (Camptosar)FDA LinkGeneric 10/2009 - 09/2003
5	MucinsIBA 10/2009 - 09/2003
4	NF-kappa B (NF-kB)IBA 06/2008 - 12/2005
3	Pharmaceutical PreparationsIBA 01/2009 - 09/2003
2	Lapatinib (GW572016)FDA Link 01/2019 - 11/2012
2	Cytotoxins (Cytolysins)IBA 01/2019 - 01/2007
2	Paclitaxel (Taxol)FDA LinkGeneric 01/2019 - 11/2012
2	dacomitinibIBA 01/2018 - 01/2017
2	AnthracyclinesIBA 08/2017 - 05/2016
2	Cyclophosphamide (Cytoxan)FDA LinkGeneric 08/2017 - 05/2016
2	AntiemeticsIBA 01/2015 - 01/2015
2	CytokinesIBA 06/2008 - 08/2007
2	Phenobarbital (Luminal)FDA Link 06/2007 - 01/2007
2	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 04/2007 - 12/2005
2	CaspasesIBA 02/2007 - 07/2006
2	Fibroblast Growth Factor 7 FDA Link 09/2005 - 07/2002
2	Methotrexate (Mexate)FDA LinkGeneric 12/2002 - 07/2002
1	ChloridesIBA 01/2018
1	crofelemer (SP-303)IBA 01/2018
1	Doxorubicin (Adriamycin)FDA LinkGeneric 08/2017
1	Epirubicin (Ellence)FDA LinkGeneric 05/2016
1	Fluorouracil (Carac)FDA LinkGeneric 05/2016
1	Rituximab (Mabthera)FDA Link 08/2013
1	Matrix Metalloproteinases (MMPs)IBA 07/2013
1	Biomarkers (Surrogate Marker)IBA 07/2013
1	Oxygen (Dioxygen)IBA 01/2013
1	Suppositories (Vaginal Suppositories)IBA 01/2013
1	Misoprostol (Cytotec)FDA LinkGeneric 01/2013
1	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 11/2012
1	Drug CombinationsIBA 11/2012
1	MitogensIBA 02/2010
1	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 02/2010
1	ProstaglandinsIBA 01/2010
1	Dinoprostone (PGE2)FDA Link 01/2010
1	Alprostadil (Muse)FDA LinkGeneric 01/2010
1	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA 01/2010
1	Epoprostenol (Prostacyclin)FDA LinkGeneric 01/2010
1	Type I DNA Topoisomerases (Topoisomerase I)IBA 06/2009
1	Cholinergic Agents (Cholinergics)IBA 12/2008
1	GlucuronidaseIBA 12/2008
1	Transcription Factors (Transcription Factor)IBA 06/2008
1	human FGF20 protein (velafermin)IBA 04/2007
1	Sucrose (Saccharose)IBA 09/2006
1	Biological ProductsIBA 01/2004
1	Interleukin-11 (Interleukin 11)IBA 12/2002

Therapy/Procedure

33	Drug Therapy (Chemotherapy) 01/2019 - 07/2002
12	Therapeutics 01/2019 - 02/2004
12	Radiotherapy 01/2019 - 02/2004
2	Aftercare (After-Treatment) 01/2007 - 09/2003
1	Adjuvant Chemotherapy 05/2016